Absorption Codeine is absorbed within the gastrointestinal tract with maximum plasma focus developing sixty minutes article administration. The presence of a large-fat, significant-calorie food did not drastically influence the PK of codeine.

In case you are employing a liquid form, make use of a medication-measuring device or spoon to meticulously evaluate the prescribed dose. Usually do not use a family spoon since you may not get the proper dose. In case your liquid sort is usually a suspension, shake the bottle nicely before Each and every dose.

Promethazine hydrochloride and codeine phosphate syrup is indicated to the non permanent reduction of coughs and higher respiratory signs associated with allergy or even the popular cold.

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The concomitant utilization of Promethazine HCl and Codeine Phosphate Oral Alternative with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor may possibly result in lower codeine ranges, bigger norcodeine stages, and fewer metabolism by way of 2D6 with resultant lessen morphine stages.

Promethazine hydrochloride wasn't mutagenic during the in vitro bacterial reverse mutation assay or clastogenic inside the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.

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Disorders OF USE: The information With this database is meant to supplement, not substitute for, the knowledge and judgment of Health care specialists. The information is just not meant to go over all feasible takes advantage of, Instructions, safety measures, drug interactions or adverse consequences, nor should really it be construed to indicate that utilization of a specific drug is Harmless, acceptable or helpful for you personally or anyone else.

Codeine is one click here of the By natural means taking place phenanthrene alkaloids of opium derived from your opium poppy; it is classed pharmacologically being a narcotic analgesic.

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Hold promethazine/codeine out website on the get to of youngsters. Promethazine/codeine is a managed compound as it is often misused or lead to dependence. Shop promethazine/codeine in a safe position to guard it from theft. It is unlawful to provide or give absent this medication.

Small website children Postmarketing instances of respiratory melancholy, like fatalities, are documented with utilization of promethazine in pediatric clients. Concomitant administration with other respiratory depressants may well raise the hazard of respiratory click here despair.

If adrenal insufficiency is diagnosed, handle with physiologic replacement doses of corticosteroids. Wean the affected person off in the opioid to allow adrenal purpose to Get better and go on corticosteroid procedure until finally adrenal operate recovers. Other opioids could get more info be attempted as some instances claimed utilization of a distinct opioid without recurrence of adrenal insufficiency. The information obtainable would not determine any specific opioids as being far more very likely to be affiliated with adrenal insufficiency.